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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Progestogen Female Steroids Estrogen Supplemental 17 alpha Estradiol manufacturer

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Progestogen Female Steroids Estrogen Supplemental 17 alpha Estradiol 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;BItcoin 
Special Groups: Anabolic Steroid Powder (89)
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: bodybuilding steroid
Production Capacity: 5000kg per month
Delivery Date: within 24 hours after payme...
CAS No.: 57-91-0
color: white
Alias: 17alpha-Estradiol,Epiestrad...
package: safe discreet package
lead time: within 24hour after payment...
Delivery time: 5-7 days
Means of Transport: Ocean,Air;express
Packing: disguised package
Brand Name: 17alpha-Estradiol
Purity: 99%
appearence: powder
MOQ: 10 grams
payment methods: T/T, Westeron Union, Money ...
Standard: USP 36

17alpha-Estradiol is a biological active estrogen in human breast cancer cells
17alpha-Estradiol has important autocrine functions in the adult brain

17 alpha Estradiol Progestogen Female Steroids Supplemental Estrogen 


17alpha-Estradiol

Alias: Epiestradial; 17a-Estradiol (8CI); 1, 3, 5-Estratriene-3, 17a-diol; 13b-Methyl-1, 3, 5(10)-gonatriene-3, 17a-diol; 17-Epiestradiol; 17a-Oestradiol; 3, 17-Dihydroxyestratriene; NSC 20293; Oestra-1, 3, 5(10)-triene-3, 17a-diol; A-Estradiol; 

Purity: 99% min. 

CAS Registry Number: 57-91-0

Einecs No: 200-354-8

MF: C18H24O2

MW: 272.38

Purity: 99%

Appearance: White Solid

Melting point: 176-180º C. 

Density: 1.17 g/cm3

Boiling Point: 445.9 ° C at 760 mmHg

Melting Point: 176-180 ° C(lit. )

Flash Point: 209.6 ° C

Storage Temperature: 0-6° C

Refractive index: 1.599

Solubility: Ethanol: 50 mg/mL, clear, colorless

Descrption


17alpha-Estradiol (known as α -Estradiol or 17 α -Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17alpha-Estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17alpha-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer's disease and ischemic stroke. 


Application: 


1.Sexual development:


The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol enhances breast development, and is responsible for changes in the body shape, affecting bones, joints and fat deposition. Fat structure and skin composition are modified by estradiol.


2.Male reproduction: 


The effect of estradiol (and estrogens) upon male reproduction is complex. Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells and the Sertoli cells of immature mammals. It functions (in vitro) to prevent apoptosis of male sperm cells.


Several studies have noted sperm counts have been declining in many parts of the world, and estrogen exposure in the environment has been postulated to be the cause.

Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis.

Males with sex chromosome genetic conditions, such as Klinefelters syndrome, will have a higher level of estradiol.


3.Bone


Estradiol has a profound effect on bone. Individuals without it (or other estrogens) will become tall and eunuchoid, as epiphyseal closure is delayed or may not take place. Bone structure is affected also, resulting in early osteopenia and osteoporosis. Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency.


4.Liver


Estradiol has complex effects on the liver. It can lead to cholestasis. It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.


5.Brain


Estrogens can be produced in the brain from steroid precursors. As antioxidants, they have been found to have neuroprotective function.


Specification


Estradiol

Batch Size

Quantity              

1kg

Manufacturing Date

2016.12.08

Batch No.

20161208

Expiry Date

2018.12.18

Report Date

2016.12.17

Reference Standard

USP 34

Packing

Foil bag

TEST

ACCEPTANCE CRITERIONS

RESULTS

Identification

Infrared Absorption

Positive

Characteristics

White or creamy white, crystalline powder

conform

Melting point

173 ~ 179degree

177~ 179degree

Specific  rotation

76°~83°

78.5°

Water

≤3.5%

pass

Assay

97 .0~ 103.0percent

99.37%

Loss on drying

≤0.5percent

0.21%

Related substances

total impurities ≤1.0percent

Pass

Residual solvents

ethanol ≤0.5percent

Pass

Conclusion

     This batch  complies with USP 34



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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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