Post Offer Free
Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Anti-Ulcer Drug Misoprostol 59122-46-2 Raw Powder manufacturer

2nd

Gold Index: 167643

You are here: home  > Prohormone Powder  > Anti-Ulcer Drug Misoprostol 59122-46-2 Raw Powder

Anti-Ulcer Drug Misoprostol 59122-46-2 Raw Powder 

Qty (Other,ml) Unit Price (160.0~290.0 USD)
100 - 199 160
200 + 290
Trade Term: FOB 
Payment Terms: T/T,WU,Money Gram;bitcoin 
Special Groups: Bodybuilding Suppplements (165)
Place of Origin: Hubei, China (Mainland) 
inquire skype
Add to My Favorites
HiSupplier Escrow
Share |

Product Detail

Model No.: Misoprostol(59122-46-2)
Production Capacity: 100000L/WEEK
Delivery Date: with 6 working hours
service: resend guarantee
Supply Ability: Mass Stock
Model Number: 59122-46-2
Usage: Bodybuilding; Male enhancem...
Shipping: 3-7 Days / Door-to-Door
Means of Transport: Air
Packing: brand new
package: Special disguised packaging...
Payment Terms: Western Union, MoneyGram, B...
Certification: ISO
Active-Life: 7-9 days
Lead Time: Within 12 Hours After Payme...

Do not take misoprostol to prevent ulcers if you are pregnant or plan to become pregnant. Misoprostol may cause miscarriages, premature labor

Anti-Ulcer Drug Misoprostol 59122-46-2 Raw Powder

Top Purity Pharmaceutical Raw Material Powder CAS: 59122-46-2Misoprostol






1. Description


1). Biological Activity: Cytoprotective prostaglandin E 1 analog that displays agonist activity at EP receptors. K i values are 120, 250, 67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors respectively. Prevents NSAID-induced gastric ulceration. Use for gastric and duodenal ulcers, hemorrhagic gastritis, acute gastric mucosal lesions and other diseases

2). The first chemical synthesis of prostaglandin E1 class anti-ulcer drug, a strong inhibition of gastric acid secretion and prevent ulcer formation, can inhibit gastric acid secretion and gastric acid include basic due histamine pentagastrin, food or coffee stimulation gastric acid secretion, but also to reduce gastric acid secretion at night. It is the first clinical application of anti-ulcer drugs. The extension of ulcer recurrence than violate receptor antagonist, but the effect is less than relieve peptic ulcer pain receptor antagonist island. For gastric and duodenal ulcers, especially for cases of low levels of prostaglandins.


3). Misoprostol is a medication used to start labor, induce abortions, prevent and treat stomach ulcers, and treat postpartum bleeding due to insufficient contraction of the uterus. For abortions it is used with mifepristone . It is a synthetic prostaglandin E1 (PGE1).
Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning that it is known to result in negative fetal outcomes if taken during pregnancy. Uterine rupture may occur.

2. Usage


Misoprostol acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration.

Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.

However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol,but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses are the main issues impairing compliance with therapy.

3. Misoprostol Application


1). Misoprostol is a synthetic analogue of E1, its role is to make the woman's uterus muscles and tissues become loose, in order to achieve increased cervix dilation purposes, safe way to terminate pregnancy.
Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell.


2). Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).


3). Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.

4). The most commonly reported adverse effect of taking a misoprostol orally for the prevention of stomach ulcers is diarrhea. In clinical trials, an average 13% of patients reported diarrhea, which was dose-related and usually developed early in the course of therapy (after 13 days) and was usually self-limiting (often resolving within 8 days), but sometimes (in 2% of patients) required discontinuation of misoprostol.

5). The next most commonly reported adverse effects of taking misoprostol orally for the prevention of gastric ulcers are: abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation, but none of these adverse effects occurred significantly more often than when taking placebos. In practice, fever is almost universal when multiple doses are given every 4 to 6 hours.

6). Misoprostol should not be taken by pregnant women to reduce the risk of NSAID-induced gastric ulcers because it increases uterine tone and contractions in pregnancy, which may cause partial or complete abortions, and because its use in pregnancy has been associated with birth defects.


Product NameMisoprostol
CAS59122-46-2
Package1kg/aluminium foil bag
Usagecan be used as pharmaceutical material
Minimum order quantity100g
passmentProfessional team special for package and shipment and staring
ShippingBy express courier
Payment optionsWestern Union, MoneyGram, T/T,Bank transfer




Product Tags:

raw hormone powders

       

anabolic steroid hormones

  


Ms. Gina
skype Ms. Gina
Manager
Tel: 86-27-88211875
Mobile: 188 7222 0799
Contact to this supplier

Didn't find what you're looking for? Post Buying Lead or contact HiSupplier Customer Service Center  for help!

Related Search

Find more related products in following catalogs on Hisupplier.com

Other products from this supplier

Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

Follow Us: Follow us on facebook Follow us on linkedin Follow us on Twitter

Gina:   skype
Service:   skype

You May Like: