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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Antineoplastic Plant Extract Vinblastine Powder manufacturer

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Antineoplastic Plant Extract Vinblastine Powder 

Price: 90.0 USD 
Payment Terms: T/T,D/A,WU,Money Gram;Bitcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: Vinblastine Sulfate
Production Capacity: 500kg//month
Delivery Date: 4-15days
CAS No.: 143-67-9
Alias: Vinblastine
usage: Vinblastine
price: Vinblastine price
effects: Vinblastine
Appearance: Vinblastine powder
Means of Transport: Ocean,Air;Express
Packing: disguise package or as requ...
Brand Name: gongchuang
Purity: 99%
source: Vinblastine from China
supplier: Vinblastine supplier
Usage: Vinblastine for medical
purity: 99% Vinblastine
Standard: USP/BP/USP Vinblastine

1,Vinblastine has vasodilating, blood thinning, and memory-enhancing actions;
2,Vinblastine is used to treat arteriosclerosis
3,Vinblastine powder

Common name:  Vinca Rosea Extract

Latin name: Uncaria rhynchophylla(miq.)Jacks /Radix Ranunculus Ternati

Part Used: Herb

vinblastine Appearance: Brown powder

vinblastine Product Specification: 

Ratio: 4:1~20:1 ; Straight Powder

vinblastine (Catharanthine) >95%,

Vinpocetine > 98%

Test Method: HPLC, UV

Origin: China


 Vincristine Sulfate Test Report(COA):


Product
Vincristine SulfateReport No.9070080201506065
Batch No.B2150030Test DateJun.28,2015
Quality730gManuf. DateJun.27,2015
Packaging50g/bottleRetest DateJun.26,2018
Standard USP35
TestRequirementsResultsVal.
AppearanceWhite to slightly yellow ,amorphous
or crystalline powder ,odorless
White powderComplies
SolubilityFreely soluble in water,soluble in 
methanol,slightly soluble in ethanol
CompliesComplies
Identification
A.infrared absorption
B.sulfate
Complies to the reference standard;
Corresponding to test for sulfate
Complies
Complies
Complies
Complies
PH3.5-4.53.9Complies
Loss on drying≤12.0%8.32%Complies
Ralated Substances:
Any individual impurity
Total impurities
 
≤1.0%
≤4.0%
 
0.76%
1.8%
 
Complies
Complies
Residual Solvent:
Ethanol
Methanol
Acetone
Chloroform
Benzene
 
≤0.5%
≤0.3%
≤0.5%
≤0.006%
≤0.0002%
 
0.1%
0.002%
0.0003%
0.0008%
<0.00001%
 
Complies
Complies
Complies
Complies
Complies
Microbial Limit:
Bacteria
Mold and yeast
Escherichia coil
 
≤500cfu/g
≤50cfu/g
Not Found/g
 
<20cfu/g
<20cfu/g
Not Found/g
 
Complies
Complies
Complies
Assay95.0%~105.0%96.7%Complies
ConclusionThe products complies with the requirements of USP 35 standard.


Introduction of Vinca Rosea Extract:

Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).

 

Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.

Microtubule disruptive drugs like vinblastine, colcemid, nocodazole have been reported to act by two mechanisms. At very low concentrations they suppress microtubule dynamics and at higher concentrations they reduce microtubule polymer mass. Recent findings indicate that they also produce microtubule fragments by stimulating microtubule minus-end detachment from their organizing centers. Dose-response studies further indicate that enhanced microtubule detachment from spindle poles correlate best with cytotoxicity.

 

Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. It is also used to treat histiocytosis according to the established protocols of the Histiocytosis Association of America.


Function of Vinca Rosea Extract:

1. It has vasodilating, blood thinning, and memory-enhancing actions.

2. It acts as a cerebral stimulant and vasodilator.

3. It is used to treat arteriosclerosis.

4. It is very effective in curing dementia caused due to insufficient blood supply to the brain.

5. It interferes with cells' ability to synthesize DNA and RNA.

 

Production proces

Raw Material → Immersion in water → Filtering → Purification → Concentration in Vacuum → Killing of Bacteria → Drying → Powder


Ms. Gina
skype Ms. Gina
Manager
Tel: 86-27-88211875
Mobile: 188 7222 0799
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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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