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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China 99% High Purity Pharmaceutical Raw Powder Gefitinib manufacturer

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99% High Purity Pharmaceutical Raw Powder Gefitinib 

Qty (Other,g) Unit Price (60.0~620.0 USD)
10 - 199 60
200 - 499 290
500 - 799 360
800 - 999 520
1000 + 620
Trade Term: FOB 
Payment Terms: T/T 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: Gefitinib 184475-35-2
Production Capacity: 100000L/WEEK
Delivery Date: with 6 working hours
service: resend guarantee
Supply Ability: Mass Stock
CAS Number: 184475-35-2
Usage: Bodybuilding; Male enhancem...
Shipping: 3-7 Days / Door-to-Door
Means of Transport: Air
Packing: brand new
package: Special disguised packaging...
Payment Terms: Western Union, MoneyGram, B...
Certification: ISO
Active-Life: 7-9 days
Lead Time: Within 12 Hours After Payme...

99% Purity Pharmaceutical Raw Powder CAS 184475-35-2 Gefitinib
99% High Purity Pharmaceutical Raw Powder Gefitinib
whatsapp008618872220816

99% Purity Pharmaceutical Raw Powder CAS 184475-35-2 Gefitinib

99% High Purity Pharmaceutical Raw Powder Gefitinib


Product Description

Gefitinib

Synonyms: IRESSA;GEFITINIB;AKOS 91371;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine;ZD 1839;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-;Gefitinib(TINIBS)
CAS: 184475-35-2
MF: C22H24ClFN4O3
MW: 446.9
Chemical Properties Light-Yellow Crystalline Powder
Usage Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
Usage Gefitinib is an antineoplastic.
Biological Activity Orally active, selective inhibitor of EGFR tyrosine kinase (IC 50 = 23-79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts.
Gefitinib introduction:
Gefitinib, is a drug used for certain breast, lung , and other cancers, also known as Iressa, a selective epidermal growth receptor (EGFR) tyrosine kinase inhibitor, for the treatment of prior locally advanced or metastatic non-chemical treatment or unsuitable for chemotherapysmall cell lung cancer (NSCLC).
Gefitinib is the first selective inhibitor of epidermal growth receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a family of receptors which includes Her1(erb-B1), Her2(erb-B2), and Her 3(erb-B3). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways. These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).
Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.

Gefitinib Specification:


Tests

Specification

Results

Appearance

Slight white to white crystalline powder

White crystalline powder

Identification IR(1)

Conforms to the refence

Conforms to the refence

Melting Point

194.0~198.0°C

196.0~197.0°C

Water(KF)

≤0.30%

0.05%

Assay (HPLC)

≥99.0%

99.9%

Individual Purity (HPLC )
≤0.20%
0.09%
ConclusionConform with company standard


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Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T Bank Transfer, Western Union and MoneyGram Available.
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.

Our advantage
1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;
2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we 're sure they can satisfy you well enough;
3. Package: Professional packing with professional materials
4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
5. Service: Best Service with after-sales service and consultation


Ms. Gina
skype Ms. Gina
Manager
Tel: 86-27-88211875
Mobile: 188 7222 0799
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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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Service:   skype

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