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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Cancer Therapy Supplement Natural Powder Axitinib CAS 319460-85-0 manufacturer

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Cancer Therapy Supplement Natural Powder Axitinib CAS 319460-85-0 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: Anti-Cancer
Production Capacity: 500kgs/month
Delivery Date: within 48hours after receiv...
CAS No.: 319460-85-0
Apperance: white power
Qualitification: ISO 9001, KOSHER,UKAS
Grade: Pharm.grade
Means of Transport: Ocean,Land,Air;Courier Expr...
Packing: discreet
Brand Name: YCGC
Purity: 99%
Payment: T/T,West Union,Money Gram,e...
Usage: Anti-Cancer
Price: change according to the mar...

Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Sold Only for scientific research purpose, shall not be used for human

Cancer Therapy Supplement Natural Powder Axitinib CAS 319460-85-0


Attention:  Sold Only for scientific research purpose, shall not be used for human body.


Description

Axitinib is a selective and oral inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases 1, 2 and 3 with .

Axitinib inhibited the phosphorylation of VEGFR-1, 2 and 3 with IC50 values of 1.2 nM, 0.2 nM and 0.1 to 0.3 nM in cells, respectively. In HUVEC cells, Axitinib inhibited VEGFR-2 stimulated cell survival with about 1000-fold selectivity against FGFR-1. Axitinib also significantly suppressed the phosphorylation of VEGF downstream signaling molecules including Akt, eNOS and ERK1/2. Besides that, axitinib inhibited VEGFR-2 phosphorylation with EC50 value of 0.49 nM in vivo. It delayed tumore growth of human xenograft tumors in mice such as M24met, HCT-116 and SN12C .

 

General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.


Chemical Name:Axitinib

Molecular Formula:C22H18N4OS

Formula Weight:386.47

CAS No.:319460-85-0

Assay:99%

Appearance:Off-White Solid powder

Storage:Shading, confined preservation

Usage:Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Applications:

1.Axitinib is indicated for kidney cancer. Axitinib is a kinase inhibitor shown to inhibit the vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3) implicated in angiogenesis and tumor growth leading to cancer progression.Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.


2.The AXIS trial was a phase 3 randomized trial that showed the efficacy of this drug. In this study it was showed that axitinib may increase progression-free survival (PFS) compared to sorafenib in patients with metastatic renal cell carcinoma who previously had failed to first-line therapy with sunitinib, bevacizumab plus interferon-alfa, temsirolimus, or cytokines. 389 patients (54%) had received 1 prior sunitinib-based therapy, 251 patients (35%) had received 1 prior cytokine-based therapy (interleukin-2 or interferon-alfa), 59 patients (8%) had received 1 prior bevacizumab-based therapy, and 24 patients (3%) had received 1 prior temsirolimus-based therapy. The baseline demographic and disease characteristics were similar between the axitinib and sorafenib groups with regard to age (median 61 years), gender (72% male), race (75% white and 21% Asian), and Eastern Cooperative Oncology Group (ECOG) performance status (55% 0, 45% 1), and histology (99% clear cell)


3.In this study they recruited 723 patients (median age 61 years) with metastatic renal cell carcinoma; they were randomized (1:1) without blinding to axitinib 5mg (N = 361) twice daily versus sorafenib 400mg (N = 362) twice daily; allocation concealment was not done. All patients had renal clear-cell carcinoma that progressed despite first-line therapy with sunitinib, bevacizumab plus interferon-alfa, temsirolimus, or cytokines. Increased Axitinib dose was allowed for patients without hypertension or adverse reactions


4.Progression free survival (PFS) was defined as time from randomization to either first documentation of disease progression (per independent blinded radiology review of images) or death due to any cause. The median duration of axitinib therapy was 6.4 months and sorafenib therapy was 5 months. Disease progression or relapse occurred in 160 patients (44%) in axitinib group and 180 patients (50%) in sorafenib group. There was a statistically significant advantage for axitinib over sorafenib for the endpoint of PFS. There was no statistically significant difference between the arms in OS. Comparing axitinib versus sorafenib in intention-to-treat analysis, the PFS was 6.7 months in the axitinib group versus 4.7 months in the sunitinib group; hazard ratio was 0.665 (95% CI 0.544-0.812); one-sided P < 0.0001, and the objective tumor response was 19% versus 9% respectively (P = 0.0001, NNT 10)


Our advantages:

Over 15years specialized in this field,Professional & Experienced sevices provided.

1. Best prices with High quality.We have complete QA&QC system;steroid powder purity is more than 99% hplc. We use the right recipe to cook the injectable steroid oil. All our order will send out after passing the test exam. 

2. Rich experienced in delivering the parcels to you.The most disguise package and the most professional shipping company to ensure safe delivery. . 

3. Enough stock ensure the prompt delivery time.

4. Good after-sales service.

5. Specials are possible when the order is big enough.

6. The most important thing is that we have resend policy to protect you 100%.


Packaging & Delivery:

We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed.


Payment & Shipping Terms:

Minimum Order Quantity:25KG (25KG/Drum

Price:Negotiable

Packing:25kg/drum or as required

Delivery Time: within 24hours after receiving full payment.

Payment terms:T/T,Western Union,MoneyGram.

Supply ability:200kg/month


How to proceed an order: 

1st: Please let me know what you need-Which product/Cas No. quantity, and the destination country. 

2nd: You send us the purchase order once we cme to an agreement on all details. 

3rd: Parcel would be delivered upon full payment received.

4th: Express Tracking No.will be provided about the parcels.

5th: You will get the parcels in 7days.

6th: After-sales service would be provided after you receive parcels.


Should you have any inquires please feel free to contact me ,kathelin(at) yccreate(doc)com.



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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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