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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Zytiga/Abiratas/Abiraterone acetate CAS 154229-18-2 Treat prostate cancer; manufacturer

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Zytiga/Abiratas/Abiraterone acetate CAS 154229-18-2 Treat prostate cancer; 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: anti-cancer
Production Capacity: 100kgs/month
Delivery Date: within 48hours after receiv...
CAS No.: 154229-18-2
MOQ: 10G
delivery: 24hours after receiving pay...
Usage: anti-cancer
Price: Factory price(Negociable)
Means of Transport: Ocean,Land,Air;Courier Expr...
Packing: discreet pkg
Brand Name: YCGC
Purity: 99%min
Payment: T/T,Western Union,Moneygram...
Pass custom: 99%
User: Adult

The word has different meanings. Steroids are chemicals, often hormones, that your body makes naturally.
You need a healthy balance of them to grow.

Zytiga/Abiratas/Abiraterone acetate CAS 154229-18-2 Treat prostate cancer;


product Name: Abiraterone Acetate

Synonyms: (3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester); Abiraterone Acetate; CB 7630; (3beta,8xi,9xi,14xi)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate; Zytiga, Abiratas, Abretone, Abirapro

MF: C26H33NO2

MW: 391.5457

CAS: 154229-18-2

 

Abiraterone Acetate Description:

Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) - i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. It is a prodrug to the active agent abiraterone, and is marketed by Janssen Biotech under the trade name Zytiga. In addition, Intas Pharmaceuticals markets the drug under the trade name Abiratas, Cadila Pharmaceuticals markets the drug as Abretone, and Glenmark Pharmaceuticals as Abirapro.

 

Medical uses:

Abiraterone acetate is indicated for use in combination with prednisone as a treatment for metastatic castration-resistant prostate cancer. In Australia it is covered by the Pharmaceutical Benefits Scheme when being used to treat castration-resistant prostate cancer and given in combination with  (subject to the conditions that the patient is not currently receiving chemotherapy, is either resistant or intolerant of docetaxel, has a WHO performance status of<2, and his disease has not since become progressive since treatment with PBS-subsidised abiraterone acetate has commenced).

 

Mechanism of action:

Abiraterone, the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17-hydroxy derivatives by its 17-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens 

 

Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Application:


Abiraterone acetate is indicated for use in combination with prednisone as a treatment for metastatic castration-resistant prostate cancer. It has received FDA (28 April 2011), EMA (23 September 2011), MHRA (5 September 2011) and TGA (1 March 2012) approval for this indication In Australia it is covered by the Pharmaceutical Benefits Scheme when being used to treat castration-resistant prostate cancer and given in combination withprednisone/prednisolone (subject to the conditions that the patient is not currently receiving chemotherapy, is either resistant or intolerant of docetaxel, has a WHO performance status of<2, and his disease has not since become progressive since treatment with PBS-subsidised abiraterone acetate has commenced).


Our advantages:

Over 15years specialized in this field,Professional & Experienced sevices provided.

1. Best prices with High quality.We have complete QA&QC system;steroid powder purity is more than 99% hplc. We use the right recipe to cook the injectable steroid oil. All our order will send out after passing the test exam. 

2. Rich experienced in delivering the parcels to you.The most disguise package and the most professional shipping company to ensure safe delivery. . 

3. Enough stock ensure the prompt delivery time.

4. Good after-sales service.

5. Specials are possible when the order is big enough.

6. The most important thing is that we have resend policy to protect you 100%.


Packaging & Delivery:

We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed.


Payment & Shipping Terms:

Minimum Order Quantity:25KG (25KG/Drum

Price:Negotiable

Packing:25kg/drum or as required

Delivery Time: within 24hours after receiving full payment.

Payment terms:T/T,Western Union,MoneyGram.

Supply ability:200kg/month


How to proceed an order: 

1st: Please let me know what you need-Which product/Cas No. quantity, and the destination country. 

2nd: You send us the purchase order once we cme to an agreement on all details. 

3rd: Parcel would be delivered upon full payment received.

4th: Express Tracking No.will be provided about the parcels.

5th: You will get the parcels in 7days.

6th: After-sales service would be provided after you receive parcels.


Should you have any inquires please feel free to contact me ,kathelin(at) yccreate(doc)com.




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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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