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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Sarms Acadesine Ampk Activator Aicar CAS 2627-69-2 fat-loss and endurance-enhancing manufacturer

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Sarms Acadesine Ampk Activator Aicar CAS 2627-69-2 fat-loss and endurance-enhancing 

Price: 2.79 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: bodybuilding
Production Capacity: 2000kgs/month
Delivery Date: within 3days after received...
CAS No.: 2627-69-2
MOQ: 10g
Payment: T/T,Western Union,Moneygram...
Grade: Pharmaceutical Grade
User: Adult
Means of Transport: Ocean,Land,Air;Courier Expr...
Packing: discreet package
Brand Name: ycgc
Purity: 99%
Apperance: White powder
package: disguised and discreet pkg
Usage: fat loss

Aicar CAS 2627-69-2 fat-loss and endurance-enhancing.
Human equivalent dosing would be about 1 gram daily.
AICAR to Reduce Obesity-Induced.
99%

Sarms Acadesine Ampk Activator Aicar CAS 2627-69-2 fat-loss and endurance-enhancing 


AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, 5-aminoimidazole-4-carboxamide ribonucleoside, acadesine) is each of several interesting things. First, it's an important pharmacological research agent, used principally as an AMPK activator. It's a compound which has shown extremely impressive fat-loss and endurance-enhancing effects in laboratory animals. Further, it has considerable mystique resulting from at least some use by elite European cyclists. And lastly, it's readily available from research chemical sites and is being personally tried by many, though generally as part of stacks and combined with changes in training and/or diet.


Pause, however, may be given when considering that treatment programs for cyclists reportedly have cost in the tens to hundreds of thousands of Euros, that all reported studies in the scientific literature have used dosing which indeed would be extraordinarily costly when scaled up for human dosing, and that the experience base of bodybuilding usage at far lower doses is equivocal at best.

Aicar Spec.

Acadesine

Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE 

CAS: 2627-69-2 

EINECS: 220-097-5 

Molecular Formula: C9H14N4O5 

Molecular Weight: 258.23 

Assay: 98% 

Apperance: White or off-white powder. 

Grade:Pharmaceutical Grade

Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases.acts by entering nucleoside pools, significantly increasing levels of 

adenosine during periods of ATP breakdown


Mechanism of Action

AICAR's principal mechanism of action is activation of AMPK (AMP-activated protein kinase.) As is well known, ATP (adenosine triphosphate) is produced by mitochondria as a ready-to-use energy source for biochemical processes in the cell. These processes do not use glucose, fats, or fatty acids directly as energy sources: these must first be metabolized in the mitochondria to yield ATP. When ATP is used for energy, its first product is ADP (adenosine di-phosphate), and then - if the cell is really deprived of immediate sources of energy - finally to AMP (adenosine monophosphate.)


AMP only accumulates as a cell becomes energy-deprived. Accordingly, there's a system where the cell detects any low energy state from the concentration of AMP that's present, and activates AMPK in response.


AMPK in turn ramps up conversion of fuel sources, including fatty acids, into ATP, as well as stimulating quite a number of other systems in the cell.


Activating AMPK, therefore, causes the same cellular machinery (so to speak) to be turned on as if the cell were energy deprived, for example from intensive exercise, or from low caloric intake.


AICAR, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.


Research Dosages

A number of examples will follow showing AICAR doses uses in research studies, results from treatment, and approximate human equivalent doses, assuming an about-200 lb (90 kg) human for illustration:


In "AMPK and PPARdelta agonists are exercise mimetics":

Mice, of a strain which is genetically susceptible to obesity and diabetes, were administered AICAR at 500 mg/kg daily for 5 weeks. Their endurance capacity increased by 44%, and expression of 32 genes favorable to metabolism was increased.


Human equivalent dosing would be about 3.2 grams per day.


In "AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats":


Rats were injected subcutaneously once with AICAR at 250 mg/kg. Improvement in whole body insulin sensitivity both post-injection and at the 24 hour point was comparable to what occurs when a bout of exercise is performed rather than an AICAR injection being given.


Human equivalent dosing would, again, be about 3.2 grams per day.


In "The Full Capacity of AICAR to Reduce Obesity-Induced Inflammation and Insulin Resistance Requires Myeloid SIRT1":


Both lean and diet-induced-obese mice were administered AICAR at 150 mg/kg daily for 5 weeks. For the lean mice AICAR provided no effect on fat mass or insulin sensitivity, but significant improvement did occur for the diet-induced-obese mice. (Interestingly, the improvement was shown to be associated with reduction of the inflammatory cytokines TNFα, IL-6, and MCP-1, and required the presence of SIRT1, just as an aside, but it helps make sense of the article title.)


Human equivalent dosing would be about 1 gram daily.


Other studies may be found, but dosings will be similar to the above.


Reputed Dosage in Elite Cycling

I do not myself have a direct example known to me personally, but reputedly typical dosage has been about 500 mg/day for about four weeks prior to an event. This is lower than human-equivalent from animal research studies, but not so much so as to strain credulity. (In contrast, for example only 50 mg per day instead of 500 mg absolutely does strain credulity, let alone the 10 mg doses used by some as part of their stacks.)


How to use AICAR

In general I would recommend against using AICAR, but if wishing to do so anyway, I would use 500 mg/day for a limited period of time such as 4 weeks. 


The purpose would have to be improved endurance capacity;


Side Effects

The most concerning side effects from AICAR are the direct effects it has on your heart. It can cause enlarged growth in cardiac tissue, and it can effect blood flow. In turn, this could affect the flow of blood to a person's brain. In addition, it has been noted that defects of heart valves may also be caused by the peptide AICAR. The heart is the most important muscle in the entire body, and the last thing anyone wants to do is treat it badly. Anecdotally, some logs indicated extreme loose bowls, dry mouth, and lack of hunger.


Possible enlarged growth of heart

Possible defects to the heart valve

Problems with blood flow

Problems with blood and nutrient transfer to the brain

Problems with bowls

 


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Thank you for reading & Hope you have a nice day & enjoy a health life!

 

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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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