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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Inhibitor Pharmaceutical Raw Material CAS 284461-73-0 Sorafenib manufacturer

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Inhibitor Pharmaceutical Raw Material CAS 284461-73-0 Sorafenib 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;BItcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: pharma raw powder
Production Capacity: 5000kg per month
Delivery Date: within 24 hours after payme...
CAS No.: 284461-73-0
Sorafenib color: white
Sorafenib Alias: BAY43-9006
Sorafenib MOQ: 10grams
Sorafenib payment methods: T/T, Westeron Union, Money ...
Sorafenib Standard: USP
Means of Transport: Ocean,Air;express
Packing: disguised package
Brand Name: Sorafenib
Purity: 99%
Sorafenib appearence: powder
Sorafenib MF: C21H16ClF3N4O3
Sorafenib Usage: kinase inhibitor,Anti-Tumor...
Sorafenib lead time: within 24hour after payment...
Sorafenib Delivery time: 5-7 days

Sorafenib is a Kinase Inhibitor.
Sorafenib is an antineoplastic agent.
Sorafenib raw powder supply
Sorafenib serve with bottom price
Sorafenib


99% Purity Anti-Tumor Pharma Raw Material Sorafenib

Inhibitor Pharmaceutical Raw Material CAS 284461-73-0 Sorafenib 


Sorafenib basic info:


product Name: Sorafenib

Molecular Formula: C21H16ClF3N4O3

CAS: 284461-73-0

Assay:99%

Synonyms:BAY43-9006;  N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-                                                                              methylcarbamoyl)-4pyridyloxy]phenyl]urea;

Appearance:White to light yellow crystalline powder

Molecular Weight: 464.82495

Density: 1.454 g/cm3

Boiling Point: 523.3 °C at 760 mmHg

Melting Point: 202-204°C


Sorafenib Descrption


Sorafenib is a new multi-targeted oral drug for the treatment of tumors. Its primary development goal is to treat gastrointestinal stromal tumors and metastatic kidney cells that are not responsive or unbearable to standard therapies.


Sorafenib can selectively target certain proteins of the receptor, which is considered plays a role in molecular switching in the tumor growth process. Its indications have been in the approval by the FDA United States.



Sorafenib Application:


1. Sorafenib tosylate (284461-73-0) is commonly used as a potent RAF kinase inhibitor.

2. Sorafenib tosylate (284461-73-0) is also used as antineoplastic drug.

3. Sorafenib is used to treat liver tumor cells that can not be surgically or distantly metastasized

4. Sorafenib is used to treat neovascular tumors that can not be operated

5. Sorafenib is used to treat radioactive iodine therapy is no longer effective local recurrence or metastasis, progressive differentiation of thyroid patients


Sorafenib VS placebo


The progression-free survival of the Sorafenib group was longer than that of the placebo group (5.8 vs 2.8 months at a risk ratio of 0.51), and Sorafenib significantly improved patient quality of life compared with placebo.


Sorafenib treatment is well tolerated, with major adverse reactions being controlled diarrhea, rash, fatigue, hand, foot syndrome, hypertension, hair loss, nausea / vomiting and loss of appetite.


Sorafenib Recommend Dosage


Recommended Dosage: Sorafenib is recommended for 0.4 g (2x0.2g) twice daily for fasting or with low fat and lipid diet.

The clear half-life of sorafenib is about 25-48 hours. Compared with single dose administration, repeated administration of 7 days to achieve 2.5-7 times the accumulation.


After 7 days of administration, the plasma concentration of sorafenib reached steady state, and the average plasma concentration was less than 2.


Sorafenib was given about 3 hours after oral administration to the highest plasma concentration. Moderate fat diet is similar to bioavailability under fasting conditions. In the high quality diet, the bioavailability of sorafenib was reduced by 29% compared with the fasting state.


When the oral formulation exceeds 0.4 g twice daily, the increase in Cmax and AUC is not linear.

In vitro, sarafenib and human plasma protein binding rate of 99.5%.


Sorafenib Specification


ItemsSpecificationsResults
AppearanceWhite to light yellow crystalline powdercomplies
Solubility

In methanol, ethanol, ethyl acetate very slightly soluble

 in water almost insoluble

complies
Any single impurity ≤0.2%0.06%
Loss on drying≤1.0%0.06%
Residue on ignition≤0.1%0.03%
Assay≥99.5% 99.87%
ConculsionThe results conform to the Specification


About US


We always willing to make a better deal for you. For regular customers we are giving great offers.

Oncce one become our customer, he will definitely return for another order.


Our mission is to provide our customer with an excellent personal service which develops long-term relationship, meeting their specific needs within budget and time frame. Ensure regulatory compliance are maximize on clients core competencies and product quality through optimized validated and controlled processes.


We have customer desired packing methods chosen and recommended by most of our customers.

We do pack as the customer desires the package to be packed....


All products are produced under GMP conditions according to Standard Operation Procedure(SOP), 

not from little underground labs or black markets, so the quality is guaranteed.


Prices depends on your order but we always encourage new clients to place sample / small orders and check our service, 

products and our communication and then gradually do your regular business with us. Of course bulk orders will enjoy discounts.


All products are bulk in stock, usually ship within 24-48 hours of your order being received and processed. Fast Express Delivery ,Available with UPS,FedEx,EMS,DHL,TNT and so on, 

secure hipping and fast T/A. US :3-5 days, UK: 4-7 days, Canada: 3-7 days, Europe: 6-10 days


If you need quality products and timely delivery then you do not need to go anywhere else,

just contact us and we serve you a lot better then anyone else

 

Our Advantages


1. Sufficient stock. We can delivery promptly at the very day when receive the payment
2. Sophisticated and professional logistic agent. We take responsibility to provide our customers with fast delivery and secure shipping
3. Well-trained and disciplined packing team. Unique ways to ship 10 grams to 100kg powders at one time to your destination. Fast and discreet shipment could be arranged for customs pass Guaranteed.
4. Packing pictures and tacking code are provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day.
5. After-sale service: Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.


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Tel: 86-27-88211875
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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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