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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China New Antiestrogen Trilostane powder 13647-35-3 adrenocortical suppressant manufacturer

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New Antiestrogen Trilostane powder 13647-35-3 adrenocortical suppressant 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: Anti-estrogen
Production Capacity: 500kgs/month
Delivery Date: within 48hours after receiv...
CAS No.: 13647-35-3
Apperance: white powder
MOQ: 10g
Grade: Medical grade
Means of Transport: Ocean,Land,Air;Courier Expr...
Packing: discreet pkg
Brand Name: YCGC
Purity: 99%
Payment: T/T,West Union,Money Gram,e...
Usage: New Antiestrogen Trilostane...
Price: change according to the mar...

New Antiestrogen Trilostane powder 13647-35-3
Trilostane is a steroidogenesis inhibitor which is used in the treatment of Cushing's syndrome.
99%

New Antiestrogen Trilostane powder 13647-35-3 adrenocortical suppressant


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Trilostane Description:

Trilostane is a steroidogenesis inhibitor which is used in the treatment of Cushing's syndrome.


It was withdrawn from human use in the United States market in April 1994.The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer. It was approved in the United States in 2008 for the treatment of Cushing's disease (hyperadrenocorticism) in dogs under the brand name Vetoryl.[8] It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. The drug is also used to treat the skin disorder Alopecia X in dogs.It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands. In studies of the drug, the most common side effects were vomiting, lack of energy, diarrhea, and weight loss. 


Trilostane should not be given to a dog that:

has kidney or liver disease;

takes certain medications used to treat heart disease;

is pregnant, nursing or intended for breeding 

The safety and effectiveness of trilostane were shown in several studies. Success was measured by improvements in both blood test results and physical symptoms (increased appetite and activity level, and decreased panting, thirst and urination).


Only one other drug, Anipryl (veterinary brand name) selegiline, is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's. The only previous treatment for the disease was the use of Mitotane (brand name Lysodren) off-label.


It has been used as a progesterone inhibitor.


A number of compounding pharmacies in the US sell the product. Since the US approval of Vetoryl in December 2008 .compounding pharmacies are no longer able to use a bulk drug product for compounding purposes, but must prepare the compounded drug from Vetoryl


It is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD), as well as of other enzymes involved in steroidogenesis.


Product Name: Trilostane 

Synonyms: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal 

Synonym: Vetoryl, Desopan, Modrastane, Modrenal, Triwinol, Win-14540

CAS: 13647-35-3 

MF: C20H27NO3 

MW: 329.43 

EINECS: 237-133-0 

Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Inhibitor;FULVICIN

Melting point  264 °C

Storage temp.  -20°C Freezer

Chemical Properties : White powders

Usage : An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer 

Usage : Antifungal, inhibits mitosis in metaphase .


Applications:

Albuterol Sulfate/Ventolin powders/Proventil powders/CAS No: 51022-70-9

It is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.

Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.


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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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