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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Good Quality Raw Material Powder CAS 124750-99-8 Losartan Potassium manufacturer

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Good Quality Raw Material Powder CAS 124750-99-8 Losartan Potassium 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;BItcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Air;express
Packing: disguised package
Brand Name: Losartan Potassium
Purity: 99%
Losartan Potassium appearence: powder
Losartan Potassium MF: C22H23ClKN6O
Losartan Potassium Usage: Coronary vasodilator used i...
Losartan Potassium lead time: within 24hour after payment...
Losartan Potassium Delivery time: 5-7 days
Production Capacity: 5000kg per month
Delivery Date: within 24 hours after payme...
CAS No.: 58-63-9
Losartan Potassium color: white
Losartan Potassium Alias: Losartan, Cozaar
Losartan Potassium EINECS: 200-287-4
Losartan Potassium payment methods: T/T, Westeron Union, Money ...
Losartan Potassium Standard: USP36

Losartan potassium is an angiotensin II receptor antagonist drug.
Losartan potassium is used to treat high blood pressure (hypertension).
Losartan

Angiotensin Pharma Grade Raw Powder Losartan Potassium 

Good Quality Raw Material Powder CAS 124750-99-8 Losartan Potassium


Losartan Potassium Basic Info


Product name

Losartan potassium

Original

China

CAS

124750-99-8

Molecular formula

C22H23ClKN6O

MW

462.01.

EINECS

200-287-4

Brand name

Yuancheng

Leading time

within 24 hours upon receipt of payment

Delivery

Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS

Purity

99%

Package

Discreet and Hidden package according to specific requirement

Appearance

White Powder

Certification

SGS, ISO 9001, KOSHER

Payment Terms

Western Union, Money Gram , T/T, Bitcoin,Banktransfer ect.

Minimum Order Quantity

Negotiable

Price

Negotiable

Usage

Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).


Losartan potassium Introduction:    

 

1. Losartan is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure (hypertension). It was the first angiotensin II antagonist to be marketed. under the trade name Cozaar, and is available in generic form.


2. Losartan (Cozaar) belongs to a group of drug called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.


Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.


3. Losartan is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.


 

Losartan potassium Useage:


As with all angiotensin II type 1 receptor (AT1) antagonists, losartan is indicated for the treatment of hypertension. It may also delay progression of diabetic nephropathy and is associated with a positive clinical outcome in that regard. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria or proteinuria.


Losartan is also available as losartan, acombination drug with a low-dose thiazide dluretic to achieve an additive antihypertensive effect.


How Losartan potassium works


1. Losartan potassium,Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5-carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. Losartan's bioavailability is about 32%.

 

2. Losartan potassium,Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.


Losartan potassium Specification


Items of analysis

Specification

Results

Characters

White or off white crystalline powder

off white powder

Solubility

Free soluble in water and methanol, 

very slightly soluble in chloroform

Conforms

Infraed absorption

Must similar to reference standard

Conforms

Ultraviolet absorption

Must similar to reference standard

Conforms

Test for potassium

Must be positive

positive

Water

≤0.5%

0.20%

Heavy metals

≤10ppm

<10ppm

Single impurity

≤0.2%

0.07%

Total impurity

≤0.5%

0.12%

Isopropyl alcohol

≤2000ppm

234ppm

Assay

98.5-101%

99.8%

Conclusion

Qualified


About Us


We always willing to make a better deal for you. For regular customers we are giving great offers.

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We have customer desired packing methods chosen and recommended by most of our customers.

We do pack as the customer desires the package to be packed....


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secure hipping and fast T/A. US :3-5 days, UK: 4-7 days, Canada: 3-7 days, Europe: 6-10 days


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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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