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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China High Pure Pharmaceutical Raw Powder Glyburide Glibenclamide manufacturer


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High Pure Pharmaceutical Raw Powder Glyburide Glibenclamide 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;BItcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: pharma raw powder
Production Capacity: 5000kg per month
Delivery Date: within 24 hours after payme...
CAS No.: 10238-21-8
Glibenclamide color: white
Glibenclamide Alias: Glyburide
Glibenclamide EINECS: 233-570-6
Glibenclamide payment methods: T/T, Westeron Union, Money ...
Glibenclamide Standard: EP
Means of Transport: Ocean,Air;express
Packing: disguised package
Brand Name: Glibenclamide
Purity: 99%
Glibenclamide appearence: powder
Glibenclamide MF: C23H28ClN3O5S
Glibenclamide Usage: antidiabetic
Glibenclamide lead time: within 24hour after payment...
Glibenclamide Delivery time: 5-7 days

Glibenclamide Glyburide is a second generation sulfonylurea with hypoglycemic activity.
Glibenclamide Glyburide is an antidiabetic .

Antihyperglycemic Pharmaceutical Raw Material Glyburide Glibenclamide

High Pure Pharmaceutical Raw Powder Glyburide Glibenclamide

Glibenclamide Basic Info

Product Name: Glibenclamide 


CAS: 10238-21-8 

MF: C23H28ClN3O5S 

MW: 494 

EINECS: 233-570-6 

Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organics;Amino Acids & Derivatis;Isotope Labeled Compounds;API's;Potassium channel;Ion Channels;Isotope Labelled Compounds;API;GLYNASE;Diabetes Research

Melting point : 173-175°C 

Storage temp. : 2-8°C 

Merck : 13,4491

Chemical Properties : White Crystalline Powder 

Usage : Antihyperglycemic 

Usage : Glyburide is a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic .

Glibenclamide Descrption

Glibenclamide belongs to the second generation oral sulfonylurea drug with the mechanism of action being similar as tolbutamide and the hypoglycemic effect being strongest among sulfonylurea drug. Its intensity of action is about 200 to 250 times of that of Tolbutamide. 

Glibenclamide can selectively act on the pancreatic β-cells, promote insulin secretion; can enhance the hypoglycemic effect of exogenous insulin and strengthen the post-receptor effect of insulin. It has fast oral absorption with high protein binding rate. It begins to take effect after 30 minutes with the effect being strongest at 1.5 hours and the duration of 16 to 24 hours. It has a distribution volume of 0.1L / kg, plasma protein binding rate of 90% to 95% and half-life of 4 to 8 hours. 

Glibenclamide is mainly consumed by the liver metabolism with six metabolites. Two of them are known as hydroxylated compounds with no hypoglycemic effect and is mainly excreted from the urine and a small amount is excreted by the stool. It is clinically mainly used for the treatment of mild to moderate non-insulin dependent diabetes mellitus .

Glibenclamide Application

Glibenclamide should be started at low doses. During treatment, it should be regularly checked of the urine sugar, urine ketone body, urine protein and blood sugar, blood routine examination, liver and kidney function, vision, retinal blood vessels.

(1) Patients of liver and kidney dysfunction, leukopenia, sulfa allergy, pregnant women and diabetes complicated by acidosis and acute infection should be disabled .

(2) It can cause abdominal distension, abdominal pain, anorexia, nausea and other gastrointestinal reactions. It can also appear as allergy (skin erythema or urticaria), leukopenia, granulocyte deficiency, thrombocytopenia, hypoglycemia, etc., should be immediately discontinued and treated. Among them, hypoglycemia reaction is more common .

(3) Glibenclamide and other sulfonylurea hypoglycemic agents can't be combined with thiazide diuretics or glucocorticoids .

(4) It should be avoided to taken together with anticoagulant drug such as dicoumaroline .

(5) When combined with phenylbutazone, the hypoglycemic effect can be enhanced, causing acute hypoglycemia .

(6) Combination with sulfonamides can enhance both the effect and toxicity of glibenclamide, not suitable for use .

(7) Combination with chloramphenicol can also enhance the effect and toxicity of this product; combination of two drug demands dose adjustment according to the patient's blood sugar levels, otherwise can cause hypoglycemic shock .

(8) Sulfonylurea drug can enhance the toxicity of alcohol; alcohol should be avoided during treatment . 

About US

We always willing to make a better deal for you. For regular customers we are giving great offers.

Oncce one become our customer, he will definitely return for another order.

Our mission is to provide our customer with an excellent personal service which develops long-term relationship, meeting their specific needs within budget and time frame. Ensure regulatory compliance are maximize on clients core competencies and product quality through optimized validated and controlled processes.

We have customer desired packing methods chosen and recommended by most of our customers.

We do pack as the customer desires the package to be packed....

All products are produced under GMP conditions according to Standard Operation Procedure(SOP), 

not from little underground labs or black markets, so the quality is guaranteed.

Prices depends on your order but we always encourage new clients to place sample / small orders and check our service, 

products and our communication and then gradually do your regular business with us. Of course bulk orders will enjoy discounts.

All products are bulk in stock, usually ship within 24-48 hours of your order being received and processed. Fast Express Delivery ,Available with UPS,FedEx,EMS,DHL,TNT and so on, 

secure hipping and fast T/A. US :3-5 days, UK: 4-7 days, Canada: 3-7 days, Europe: 6-10 days

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just contact us and we serve you a lot better then anyone else

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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]

Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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