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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Antitussive Drug Promethazine Hydrochlorine Promethazine Hydrochloride CAS 58-33-3 for Allergic Disorder manufacturer

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Antitussive Drug Promethazine Hydrochlorine Promethazine Hydrochloride CAS 58-33-3 for Allergic Disorder 

Price: 90.0 USD 
Payment Terms: T/T,D/A,WU,Money Gram;Bitcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Air;Express
Packing: disguise package or as requ...
Brand Name: gongchuang
Purity: 99%
source: Promethazine HCl China
supplier: Promethazine HCl supplier
Usage: for medical
purity: 99% min
Standard: USP/BP/USP
Production Capacity: 500kg//month
Delivery Date: 4-15days
CAS No.: 58-33-3
Alias: Promethazine HCl
usage: Promethazine HCl
price: Promethazine HCl price
effects: medcine raw
Appearance: powder

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Quack Detail for Promethazine hydrochloride
 

Product NamePromethazine hydrochloride
Synonymsphenothiazine hydrochloride;Promethazine Hcl
CAS58-33-3
MFC17H21ClN2S
MW320.88
EINECS200-375-2
Purity99%
AppearanceWhite Solid
GradePharma Grade
UsageFor the treatment of allergic disorders, and nausea/vomiting.
PackingFor the treatment of allergic disorders, and nausea/vomiting.
StorageStore in cool and dry area and keep away from direct sunlight.


Promethazine hydrochloride is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). Promethazine hydrochloride is available in generic form.

Promethazine hydrochloride suppositories (Brand Names: Phenadoz, Promethegan) is a phenothiazine that works by changing the actions of chemicals in your brain, and also acts as an antihistamine, used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Promethazine hydrochloride suppositories is also used to prevent motion sickness, treat nausea and vomiting or pain after surgery, and as a sedative or sleep aid. Promethazine hydrochloride suppositories are available in generic form. Common side effects of promethazine hydrochloride suppositories include dizziness, drowsiness, sleepiness, restlessness, blurred vision, dry mouth, stuffy nose, ringing in the ears, weight gain, swelling in hands or feet, impotence, trouble having an orgasm, or constipation.
  
Promethazine hydrochloride COA

Product namepromethazine hydrochloride
CAS No.58-33-3Outer Packing25KG/DRUM
Production dateAPRIL 2016Shelf lifeMARCH 2021
Standard adoptedIP
Items of analysisSpecificationResults
descriptiona white or faintly yellowish,crystalline powdera white crystalline powder
solubilityvery soluble in water,freely soluble in chloroform and in ethanol(95%)very soluble in water,freely soluble in chloroform and in ethanol(95%)
A. IR absorption spectrumpositions and relative sizes of the banks in the spectrumpositions and relative sizes of the bands in the spectrum
B.by TLCIt complies with the identification test for phenothiazinesit complies with the identification test for phenothiazine
C.Test with nitric acidforms orange colored solution and organge-red precipitatecomplies with test for chlorides
pH(10% w/v solution)4.0-5.04.31
isopromethazinenot more than 1.0%less than 1.0%
other impuritynot more than 0.5%less than 0.5%
sulphated ashnot more than 0.5%0.20%
loss on drying at 105ºCnot more than 0.5%0.20%
assay98.5-101%(on anhydrous basis)100.0%
ConclusionQualified

Product NamePromethazine hydrochloride
CAS58-33-3
MFC17H21ClN2S
MW320.88
EINECS200-375-2
Purity99%
AppearanceWhite crystalline powder
HS Code4010320000
CategoriesActive Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals ;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors
Synonyms10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride


 
What is Promethazine hydrochloride?

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the dopamine receptor D2). In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. It is available in many countries under many brand names. Promethazine was developed in the mid 1940s when a team of scientists from Rhône-Poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine
 
Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is soluble in water and freely soluble in alcohol.
Each tablet, for oral administration, contains 25 mg or 50 mg of promethazine hydrochloride. In addition each tablet contains the following inactive ingredients: dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and stearic acid.

Promethazine Hydrochloride Tablets USP, 50 mg also contain anhydrous lactose.


Usage:
 
1)Antihistaminic, antiemetic, CNS depressant.

2.For the treatment of allergic disorders, and nausea/vomiting. 

3)With aminophylline in the treatment of asthma.

4)For the treatment of allergic disorders, and nausea/vomiting.

5)Dubbed hibernation and injection for artificial hibernation.
 

Promethazine hydrochloride COA:
 

Test ItemsSpecificationTest Results
DescriptionWhite crystalline powderWhite crystalline powder
IdentificationIR , UV conformConform
Loss on drying≤0.5ml0.21ml
Residue on ignitionNot more than 0.2%0.06ml
IronNot more than 0.005%0.0018%
Heavy metalsNot more than 0.001%0.0006%
Related substancesTotal: Not more than 1.0%
Individual: Not more than 0.5%
0.32%
0.14%
E-isomerNot more than 0.3%0.19%
Organic volatile impuritiesConformsConforms
Assay99.0~101.0%99.51%
ConclusionConform with USP30


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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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