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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Trimetazidine Dihydrochloride / Citanest CAS 13171-25-0 High Quality Pharmaceutical Intermediate manufacturer

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Trimetazidine Dihydrochloride / Citanest CAS 13171-25-0 High Quality Pharmaceutical Intermediate 

Price: 90.0 USD 
Payment Terms: T/T,D/A,WU,Money Gram;Bitcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Air;Express
Packing: disguise package or as requ...
Brand Name: gongchuang
Purity: 99%
source: Promethazine HCl China
supplier: Promethazine HCl supplier
Usage: for medical
purity: 99% min
Standard: USP/BP/USP
Production Capacity: 500kg//month
Delivery Date: 4-15days
CAS No.: 13171-25-0
Alias: Promethazine HCl
usage: Promethazine HCl
price: Promethazine HCl price
effects: medcine raw
Appearance: powder

Trimetazidine dihydrochloride
Trimetazidine dihydrochloride
Trimetazidine dihydrochloride
Trimetazidine dihydrochloride

Product name: Trimetazidine Dihydrochloride
CAS: 13171-25-0
Molecular formula: C14H24Cl2N2O3
Purity: 99% min
Appearance: White powder
Usage: Antineoplastic Agents,
Packing: 25kg/drum
Delivery: Within one week after payment done.

Melting point231-235 °C(lit.)
storage temp.Refrigerator
Merck14,9705

 Trimetazidine Dihydrochloride / Citanest CAS 13171-25-0 High Quality Pharmaceutical Intermediate


Quick detail;
English name: Trimetazidine dihydrochloride
Chinese Name: Hydrochloride Trimetazidine
MF: C14H24Cl2N2O3
MW: 339.26
CAS: 13171-25-0
EINECS No.: Trimetazidine dihydrochloride 13171-25-0
Place of Origin: China (Mainland)
Type: Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote,
Grade Standard: Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade,
Usage: Animal Pharmaceuticals
Brand Name: Health
Purity: 99%
Form: White Powder

specefication;

ItemSpecification 
Specific rotation+39.5 to +41.5° 
State of solution(transmittance)Clear 98.0% min.
Chloride[cl]0.020% max. 
Ammonium [NH4]0.02% max. 
Sulfate[SO4]0.020% max
Iron[Fe]10ppm max.
Heavy metals [Pb]10ppm max
Arsenic[As2O3]1ppm max
Other amino acidsChromatographically not detectable
Loss on drying0.20% max. 
Residue on ignition[sulfated]0.10% max.
Assay99.0% min



 Trimetazidine dihydrochloride

Basic information:

Product Name: Trimetazidine dihydrochloride 
Synonyms: 1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE;TRIMETAZIDINE DI HCL;TRIMETAZIDINE DIHYDROCHLORIDE;TRIMETAZIDINE HYDROCHLORIDE;TRIMETAZIDINE 2HCL;1-((2,3,4-trimethoxyphenyl)methyl)-piperazindihydrochloride;1-(2,3,4-trimethoxybenzyl)-piperazindihydrochloride;kyurinett 
 Trimetazidine dihydrochloride CAS: 13171-25-0 
 Trimetazidine dihydrochloride MF: C14H24Cl2N2O3 
 Trimetazidine dihydrochloride MW: 339.26 
 Trimetazidine dihydrochloride EINECS: 236-117-0 
 Trimetazidine dihydrochloride Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C14 to C15;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines 
Mol File: 13171-25-0.mol 

Chemical Properties:
MP 231-235 °C(lit.)
storage temp.  Refrigerator 
Merck  14,9705 
CAS DataBase Reference 13171-25-0(CAS DataBase Reference) 

Safety Information:

Hazard Codes  Xn,Xi 
Risk Statements  22-36/37/38 
Safety Statements  26-36 
WGK Germany  3
RTECS  TM2976100
HazardClass  IRRITANT 

Usage And Synthesis:

Usage Coronary vasodilator. Antianginal 


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Mechanism of Action
Trimetazidine inhibits beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl-CoA thiolase,which enhances glucose oxidation.In an ischaemic cell,energy obtained during glucose oxidation requires less oxygen consumption than in the beta-oxidation process.Potentiation of glucose oxidation optimizes cellular energy processes,thereby maintaining proper energy metabolism during ischaemia.By preserving energy metabolism in cells exposed to hypoxia or ischaemia,trimetazidine prevents a decrease in intracellular ATP levels,thereby ensuring the proper functioning of ionic pumps and transmembrane sodium-potassium flow whilst maintaining cellular homeostasis.

Medical Uses
Trimetazidine is usually prescribed as a long-term treatment of angina pectoris,and in some countries (including France) for tinnitus and dizziness.It is taken twice a day.In 2012 European Medicines Agency (EMA) finished a review of benefits and risks of trimetazidine and recommended restricting use of trimetazidine-containing medicines just as an additional treatment of angina pectoris in case of inadequate control by or intolerance to first-line antianginal therapies.

Controlled studies in angina patients have shown that trimetazidine increases coronary flow reserve,thereby delaying the onset of ischemia associated with exercise,limits rapid swings in blood pressure without any significant variations in heart rate,significantly decreases the frequency of angina attacks,and leads to a significant decrease in the use of nitrates.

It improves left ventricular function in diabetic patients with coronary heart disease.Recently,it has been shown to be effective in patients with heart failure of different etiologies.

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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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