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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Potent Local Anesthetic Pharmaceutical Tetracaine Hydrochloride Tetracaine manufacturer

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Potent Local Anesthetic Pharmaceutical Tetracaine Hydrochloride Tetracaine 

Price: 90.0 USD 
Payment Terms: T/T,D/A,WU,Money Gram;Bitcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Air;Express
Packing: disguise package or as requ...
Brand Name: gongchuang
Purity: 99%
source: Tetracaine
supplier: Tetracaine
Usage: for medical
purity: 99% min
Standard: USP/BP/USP
Production Capacity: 500kg//month
Delivery Date: 4-15days
CAS No.: 73-78-9
Alias: Tetracaine
usage: Tetracaine
price: Tetracaine
effects: medcine raw
Appearance: powder

Pain Killer Tetracaine HCl Lidocaine Benzocaine Procaine Tetracaine
Potent Local Anesthetic Pharmaceutical Tetracaine Hydrochloride / Tetracaine

What is Tetracaine Hydrochloride  ?

 

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

Application:

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
 

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

COA: 


Product name

Tetracaine HCl

Appearance

White crystalline powder

Assay(*)

98~101.0%

100.4%

Identification

A.By UV, To match with working standard

Complies

B: Dissolve 100 mg in 10 mL of water, and add 1 mL of potassium thiocyanate
solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate
from water, and dry at 80 for 2 hours: it melts between 130 and 132 .

Complies

C. A solution of 100 mg in 5 mL of water meets the requirements of the
Tests for Chloride

Complies

PH
Chromatographic purity
Clarity

4.5~6.5

5.9

Conform to standard

Complies

Solution should be clear

Complies

Related Substances

Not more than the reference solution (0.05%)

Complies

Heavy metals

≤10ppm

<10ppm

Loss on drying

<0.5%

0.21%

Resiue on ignition

≤0.1%
0.05%
Melting range145~150°C

146~149°C
 

 
 




Description:

Tetracaine HCl

Amethocaine hydrochloride

Anethaine

Butethanol

Curtacain

Decicain

Gingicain M

Menonasal

Pantocaine

Pontocaine hydrochloride

Tetracaine hydrochloride

Tonexol

potent local anesthetic
 

Chemical properties

CAS No.: 136-47-0
Molecular formula: C15H25ClN2O2 
Nolecular weight: 300.82 
EINECS: 205-248-5
Appearance: Fine white crystalline and odorless powder
Melting point: 145~150 degree
 

Mechanism of action

Tetracaine (INN, also known as amethocaine; Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

Uses

Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5‱ (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent  hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt 

cannulations.
 

Applications:

Tetracaine is a kind of pharmaceutical raw materials used as a potent local anesthetic.

Tetracaine is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
 

Specifications:

Product NameTetracaine Hydrochloride
Molecular FormulaC15H25ClN2O2 
Molecular Weight300.82 
Molecular Structure
EINECS136-47-0
ApplicationTetracaine is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


Local Anesthetic drug

Serial NO.Product NameCAS NO.
1Procaine59-46-1
2Lidocaine137-58-6
3Prilocaine721-50-6
4Benzocaine94-09-7
5Bupivacaine2180-92-9
6Articaine23964-58-1
7Procaine HCl51-05-8
8Lidocaine HCl73-78-9
9Prilocaine HCl1786-81-8
10Aarticaine HCl23964-57-0
11Prilocaine HCl1786-81-8
12Dibucaine HCL61-12-1
13Benzocaine HCl23239-88-5
14Mepivacaine HCl1722-62-9
15Ropivacaine HCl132112-35-7
16Bupivacaine HCL14252-80-3
17Proparacaine HCL5875-06-9
18Levobupivacaine HCl27262-48-2


Product NameTetracaine HydrochlorideBatch No.FH20160830
MFG. DateAug. 30 th ,2016EXP. DateAug. 30th ,2018
Cas No.136-47-0EINECS No.205-248-5
Molecular formulaC15H24N2O2 .HClBoiling Point389.4 degree at 760 mmHg
StandardUSP 32
FunctionMain functions are as follows:
1. Local anesthetic.
2. Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.
ApplicationsApplied in medicines and dentistry fields. 
Packing1kg/bag;  25kg/Drum
Shelf Life36 months
StorageStore in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
Test ItemsSpecificationTest Results
AppearanceFine, white, crystalline, odorless powderconfirm
IdentificationA\B\C in Passconfirm
SolubilityVery soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene
confirm
USP Reference standardsUSP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
confirm
Melting point145~150 degree146.0~147.5 degree
Chromatographic purityIn Passconfirm
Related substanceNot more than the reference solution 0.05%confirm
Heavy metals≤10ppmconfirm
PH4.5-6.55.8
Residue on ignition≤0.10%0.05%
Loss on Drying≤ 0.5%0.19%
Assay98.0 -101.0%100.1%
ConclusionConfirms USP 32


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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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