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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Injectable Peptides Powder DSIP For Improve Sleep CAS:62568-57-4 manufacturer

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Injectable Peptides Powder DSIP For Improve Sleep CAS:62568-57-4 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: Improve Sleep PEPTIDE
Production Capacity: 5000kgs/month
Delivery Date: within 48hours after receiv...
CAS No.: 221231-10-3
Payment: T/T,Western Union,Moneygram...
Usage: bodybuilding
Price: change according to the mar...
Means of Transport: Ocean,Land,Air;Courier Expr...
Packing: discreet pkg
Brand Name: YCGC
Purity: 57982-77-1
Apperance: liquid
User: Adult
MOQ: 10vials

Delta Sleep-Inducing Peptide Powder DSIP Increase Sleep CAS:62568-57-4
Injectable Peptides Powder DSIP For Improve Sleep CAS:62568-57-4
DSIP Powder

Injectable Peptides Powder DSIP For Improve Sleep CAS:62568-57-4


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Description:

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities


A first study of DSIP application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design. DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning. The subjects immediately reported a feeling of sleep pressure, and sleep increased by 59% (median of total sleep time) within a 130-min interval after the treatment as compared with placebo.

 

Delayed effects on subsequent night sleep were shorter sleep onset, reduced percentage of stage 1, and better sleep efficiency. Nevertheless, sophisticated behavioral and EEG analyses revealed no sedation in the classic pharmacologic way. The results suggest that DSIP in humans is also efficacious by sustaining natural sleep functions. The compound was well-tolerated and no psychologic, physiologic, or biochemical side effects were observed.


Product Name:DSIP

Synonyms:SLEEP INDUCING PEPTIDE;WAGGDASGE;TRP-ALA-GLY-GLY-ASN-ALA-SER-GLY-GLU;TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU;TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU 4H2O;DELTA SLEEP INDUCING PEPTIDE;DELTA SLEEP-INDUCING PEPTIDE 4H2O;DSIP

CAS:62568-57-4

MF:C35H48N10O15

MW:848.81


Function

Roles in endocrine regulation

Decreases basal corticotropin level and blocks its release

Stimulates release of luteinizing hormone (LH)

Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Roles in physiological processes

Can act as a stress limiting factor.

May have a direct or indirect effect on body temperature and alleviating hypothermia.

Can normalize blood pressure and myocardial contraction.

It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.

There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion and suppression of paradoxical sleep, (PS)while some studies show no correlation.Stronger effects on sleep have been noted for the synthesized analogues of DSIP.


It may have an impact on human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.

 

Structure and Interactions

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.


Evidence supports the current belief that it is regulated by glucocorticoids.

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.


Applications:


Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.


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ABOUT US

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We're specialized in pharma raw materials ( hormone steroid powders, Steroids injectable liquids,peptides,Sarms), our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 15 years. 


Major Market: United States, United Kingdom, Australia, Canada, Sweden, Russia, Poland, Brazil, Israel, Netherlands, Germany,Spain, Switzerland, Poland and so on.


MOQ:10g

Package:Disguised & Discreet pkg

Payment:T/T,Western Union,Moneygram,bitcoin

Delivery: sent out the goods within 24hours after receiving payment.

Custom Pass rate:99%

Resend policy is available if the parcle is seized or any quality problems been found.


After-sale Service :

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Hexarelin2mg/vial

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Ipamorelin2mg/vial

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CJC-1295 without DA2mg/vial

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GHRP-25mg/vial

GHRP-65mg/vial

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DSIP           2mg/vial

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Follistatin 344      1mg/vial

Follistatin 315      1mg/vial

Epitalon10mg/vial

Pentadecapeptide Bpc 1572mg/vial





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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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