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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China High Purity SARMs Steroids Powder Mk-1775 for Bodybuilding manufacturer

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High Purity SARMs Steroids Powder Mk-1775 for Bodybuilding 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram;BItcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: sarms powder
Production Capacity: 5000kg per month
Delivery Date: within 24 hours after payme...
CAS No.: 955365-80-7
MK-1775 color: yellow
MK-1775 Alias: MK1775, MK 1775
MK-1775 Standard: USP
MK-1775 package: foil bag or as your mind
MK-1775 lead time: within 24hour after payment...
Means of Transport: Ocean,Air;express
Packing: disguised package
Brand Name: MK-1775
Purity: 99%
MK-1775 appearence: Powder
MK-1775 Molecular Formula: C27H32N8O2
MK-1775 Usage: Ovarian Cancer Effective Tr...
MK-1775 methods: T/T, Westeron Union, Money ...
MK-1775 Delivery time: 5-7 day

MK-1775 is an inhibitor of the checkpoint kinase Wee1.
New Arrived sarms steroid powder MK-1775
MK-1775 factory direct supply
MK-1775 safe shipping

SARMs Steroids Yellow Powder MK-1775 CAS 955365-80-7 For Ovarian Cancer Treatment


MK-1775 Basic Info


Product NameMK-1775
AliasMK1775, MK 1775
CAS955365-80-7
MFC27H32N8O2
MW500.59538
Purity99.50%
GradePharmaceutical Grade
Appearanceyellow powder
Brand NmaeYC
StandardUSP
StockMass Stock
Storagestore at 0-5 ℃
Packing Methodsdesigned disguised packing ways, 100% pass custom guarantee
Delivery timewithin 18 hours after payment confirmed
PaymentT/T, Western Union,Money Gram , Bitcoin
UsageMK-1775 is an inhibitor of the checkpoint kinase Wee1


What is MK-1775?


MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM).1 It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the G2 DNA damage checkpoint.1 In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging chemotherapeutic agents, is reported to induce apoptosis in vitro and potentiate the inhibition of tumor growth in vivo.


MK-1775 Application:


MK-1775 treatment led to the inhibition of Wee1 kinase and reduced inhibitory phosphorylation of its substrate Cdc2. MK-1775, when dosed with gemcitabine, abrogated the checkpoint arrest to promote mitotic entry and facilitated tumor cell death as compared to control and gemcitabine treated tumors. MK-1775 monotherapy did not induce tumor regressions. However, the combination of gemcitabine with MK-1775 produced robust anti-tumor activity and remarkably enhanced tumor regression response (4.01 fold) compared to gemcitabine treatment in p53-deficient tumors. Tumor re-growth curves plotted after the drug treatment period suggest that the effect of the combination therapy is longer-lasting than that of gemcitabine. None of the agents produced tumor regressions in p53-wild type xenografts.


MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14).


By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.



About US


Welcome to our site. Our main products cover raw steroid powder, semi-finished oil, sarms powder and peptides, all equipments for steroid process as well.

 

Our company owns a well-trained and disciplined packing team for packing with our best discreet and stealth packages. And sufficient stock to ensure the parcel can be delivered to your hand fastly and safely by DHL, TNT, FedEx, EMS, Aramex, UPS, EUB, etc.

 

If you need quality products and timely delivery then you do not need to go anywhere else,

just contact us and we serve you a lot better then anyone else. whatsapp +8618872220826 

 

Our Advantages

 

Sufficient stock. We can delivery promptly at the very day when receive the payment
2. Sophisticated and professional logistic agent. We take responsibility to provide our customers with fast delivery and secure shipping
3. Well-trained and disciplined packing team. Unique ways to ship 10 grams to 100kg powders at one time to your destination. Fast and discreet shipment could be arranged for customs pass Guaranteed.
4. Packing pictures and tacking code are provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day.
5. After-sale service: Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.


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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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