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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Nootropic Raw Powder NSI-189 Treatments For Major Depressive Disorder (MDD) CAS:1270138-40-3 manufacturer


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Nootropic Raw Powder NSI-189 Treatments For Major Depressive Disorder (MDD) CAS:1270138-40-3 

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Place of Origin: Hubei, China (Mainland) 
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Model No.: anti-depression raws
Production Capacity: 5000kgs/month
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CAS No.: 1270138-40-3
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Purity: 99%
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MOQ: 10g
Category: Pharma Raws Powder

Nootropic Raw Powder NSI-189 Treatments For Major Depressive Disorder (MDD) CAS:1270138-40-3
Nootropic Raw Powder NSI-189 Treatments For Major Depres

Nootropic Raw Powder NSI-189 Treatments For Major Depressive Disorder (MDD) CAS:1270138-40-3

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NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine created by Neuralstem, Inc. Research into NSI-189 has been heavily funded by the Defense Advanced Research Projects Agency (DARPA) and theNational Institutes of Health (NIH). 

NSI-189 Spec.

Product Name:NSI-189

Synonyms:NSI-189;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl];[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]NSI189;NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl];NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]





the Food and D rug Administration (FDA) have approved the advance to Phase 1b in the ongoing clinical trial to test its neuroregenerative compound, NSI-189.

NSA-189 is a proprietary new chemical entity that stimulates new neuron growth in the hippocampus, an area of the brain believed to be contributory in MDD and other conditions, such as Alzheimer's disease and Post-traumatic stress disorder (PTSD).  Phase 1b of the clinical trial is to test the safety and tolerability of the d rug in depressed patients.


NSI-189 is neurogenic and nootropic research agent that was developed from nicotinamide and pyrazine. Randomized controlled trials have shown that it stimulates neurogenesis or neuronal cell production in the brain. In animal studies, it has also been shown to increase the volume of hippocampus by 20% thereby reversing behavioral symptoms of depression. Such studies have shown that it may be an effective treatment for depression. It is also thought to be a promising treatment for other condition including post-traumatic stress disorder (PTSD), Alzheimer's disease and age-related cognitive problems.

NSI-189 has been proved that is thought to potentially promote increased neuronal production whilst treat depression is NSI-189. This article discusses NSI-189 and how this novel nootropic agent can revolutionize the treatment for depression, and possibly other neurodegenerative disorders.

Current treatments for major depressive disorder (MDD) mostly include the use of oral medications to modulate critical neurotransmitters in the brain. Selective serotonin reuptake inhibitors (SSRIs) are believed to be the most commonly and widely prescribed treatment for depression. Most recent research however reveals that there is a new theory regarding the cause of major depressive disorder. This theory implicates that brain physiology also influences depression rather than brain chemistry problems alone. Researchers have discovered that the disease leads to decreased hippocampal volume. Note that a healthy hippocampus is an excellent source of neural stem cells which lead to the production of neurons. Neurons on the other hand are critical for creating essential new connections in the brain. Through the production of new neurons in the hippocampal area, depression can be treated.

How NSI-189 works

This d rug was developed to address three important aspects of depression including hippocampal volume, neurogenesis and neurotransmission. NSI-189 increases the volume within the hippocampus. In so doing, hippocampal volume and healthy brain cell density is increased thereby improving mod and cognitive performance.  Aside from increasing hippocampal volume, the d rug also improves neuronal cell functionality. It works it promoting healthy neuronal cell growth whilst repair damaged areas in the brain.

NSI-189 Benefits

Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189. The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) 



Dosage and Suggestion

Studies conducted to evaluate effects of NSI-189 revealed that 40 to 80 mg daily is effective in treating depression and cognitive symptoms amongst healthy patients. In these trials, there are no serious adverse events recorded. Generally, NSI-189 is well tolerated and safe for human use.

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Sleep AidCAS NO.
Melatonine 73-31-4 
Phenibut 1078-21-3 
Suvorexant(MK-4305) 1030377-33-3 
Agomelatine 138112-76-2 
Trazodone HCL 25332-39-2 
Sertraline HCL 79559-97-0 
Trifluoperazine dihydrochloride440-17-5
 Chloral hydrate302-17-0
Tianeptine Sodium 30123-17-2 
NSI-189 1270138-40-3 
NSI-189 Phosphate 1270138-41-4
Tianeptine 66981-73-5 
Tianeptine Sulfate 1224690-84-9 
5-HTP 56-69-9
Escitalopram Oxalate 219861-08-2 

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