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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China High Purity Bulk Drug CAS 105816-04-4 Nateglinide manufacturer


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High Purity Bulk Drug CAS 105816-04-4 Nateglinide 

Price: 90.0 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Means of Transport: Ocean,Land,Air
Packing: disguise package or as requ...
Brand Name: gongchuang
Purity: 99%
source: Nateglinide source
supplier: Nateglinide supplier
Usage: Nateglinide Usage
purity: 99% min
Standard: USP/BP/USP
Production Capacity: 500kg//month
Delivery Date: 4-15days
CAS No.: 105816-04-4
Alias: Nateglinide
usage: Nateglinide usage
price: Nateglinide price
effects: Nateglinide
Appearance: powder

Antidiabetic Active Pharmaceutical Ingredients Nateglinide ;
Antidiabetic Active Pharmaceutical Ingredients Nateglinide CAS

Antidiabetic Active Pharmaceutical Ingredients Nateglinide CAS 105816-04-4

Product Name: Nateglinide
Synonyms: (-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine;ay4166;Nateglinide(H);trans-d-phenylalanin;trans-n-((4-(1-methylethyl))carbonyl)-d-phenylalanine;3-phenyl-2-(4-propan-2-yl)carbonylamino-propanoic acid;A-4166;STARLIX
CAS: 105816-04-4
MF: C19H27NO3
MW: 317.42
Product Categories: Active Pharmaceutical Ingredients;API;APIs;Health & Beauty;
Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;
Melting point : 137-141°C 
Storage temp. : Room temp
Chemical Properties : White Cyrstalline Solid 
Usage : antidiabetic KATP channel blocker 
Usage : An Amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic . 

Nateglinide Hypoglycemic agents

Nateglinide and mitiglinide, repaglinide are three commonly used non-sulfonylurea oral hypoglycemic agents for insulin secretion,it is successfully developed for the first time by the Japanese company Ajomoto , its chemical structure belongs to carbamoylmethyl-benzoic acid (CMBA), it belongs to D- phenylalanine derivatives, it is a new generation of antidiabetic drug having amino acid structure ,it is an amino acid derivative prompting insulin secretion, it is also currently the only non-sulfonylureas insulinotropic agent having amino acid structure. The mechanism is mainly through binding the pancreatic β cell sulfonylurea receptor, blocking islet cell ATP-sensitive potassium channels, leading to membrane depolarization, causing the calcium channe lopen to promote insulin secretion. This product is a new type of meal blood glucose regulator, which can effectively control the postprandial blood glucose levels, with rapid onset, short duration of action, low incidence of cardiovascular side effects and hypoglycemia and other characteristics .

Oral bioavailability is 72%, after 15min it can produce insulin secretion effect, Tmax is 0.5 ~ 0.9 h, 0.2 h insulin levels achieve peak , after 1.5 h it is similar to placebo. The plasma protein binding rate is 99%. After reaching plasmapeak , plasma concentrations decline rapidly.T1 / 2 of oral administration of 120 mg and intravenous injection 60 mg of is 1.5 to 1.7 hours, and the plasma clearance is 7.4 hours. It is metabolized in the liver by isoenzyme CYP2C9 and CYP3A4 way. The main metabolites are products after isomeric oxidation,it can be hydroxyl, diastereomers, isopropyl isomer or unsaturated aliphatic isomers.The main metabolites in plasma and urine are metabolites after the hydroxylation of isopropyl methine family (me-thine carbon) . About 2/3 nateglinide is excreted from the fecal , and the rest is excreted in the urine. Such excretion way is beneficial to elderly 2 diabetes mellitus with renal dysfunction. nateglinide eliminate T1 / 2 is 1.4 h, because nateglinide T1 / 2 is short, there is no report yet about the drug accumulation in the body . Long-term use of nateglinide does not produce drug-induced hypoglycemia caused by drug accumulation .It is used for the treatment of diet therapy, exercise therapy and mild to moderate non-insulin dependent (2 type) diabetes which taking α- glucosidase inhibitor can not control. The results show that: nateglinide can be used more physiologically for meal glucose control, there is less opportunity for contact with insulin and hypoglycemia which allows patients to flexibly plan scheduling mealtimes, which means there is medication while eating, not eating no medication .

Commerce Clause

Minimum Order Quantity:10g
Payment Terms:Western Union, MoneyGram, T/T, Bank Transfer;Bitcoin
Delivery time:Within 24 hours after receiving the payment
Leading time:4~6 working days after confirming the payment
Delivery By DHL, TNT, FedEx, HKEMS, UPS, etc.(Door to Door)
Packaging Details:Foil bag or according to customer needs
Supply Ability:Mass in stock

Nateglinide Uses

It is used for the treatment of diabetes .

Ms. Gina
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Tel: 86-27-88211875
Mobile: 188 7222 0799
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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]

Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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