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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Nootropic Supplement Drug White Powder Flumazenil CAS 78755-81-4 manufacturer


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Nootropic Supplement Drug White Powder Flumazenil CAS 78755-81-4 

Price: 1.0 USD 
Payment Terms: T/T,WU,Money Gram 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: pharma raw powder
Production Capacity: 5000kg per month
Delivery Date: within 24 hours after payme...
CAS No.: 78755-81-4
Flumazenil color: white
Flumazenil Alias: Romazicon
Flumazenil Standard: USP
Flumazenil methods: T/T, Westeron Union, Money ...
Flumazenil Delivery time: 5-7 day
Means of Transport: Ocean,Air
Packing: disguised package
Brand Name: Flumazenil
Purity: 99%
Flumazenil appearence: powder
Flumazenil Formula: C15H14FN3O3
Flumazenil package: foil bag or as you mind
Flumazenil lead time: within 24hour after payment...
Flumazenil Usage: Fumazenil is an imidazobenz...

Fumazenil is an imidazobenzodiazepine derivative.
Fumazenil a potent benzodiazepine receptor antagonist.
pharma raw material Fumazenil supply

1. Flumazenil Quick detail

Product NameFlumazenil
GradePharmaceutical Grade
Brand NameYC
AppearanceWhite power
StorageOriginal package at cool dark place

2. Fumazenil Description

Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.

3. Flumazenil Half life

Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes).

4.Flumazenil Applications

Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures.
It has been used as an antidote in the treatment of benzodiazepine overdoses.It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil's short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
It is also sometimes used to reverse the effects of benzodiazepines after surgery in a manner similar to naloxone's application to reverse the effect of opiates and opioid following surgery. This requires careful monitoring by an anesthesiologist due to potential side effects and serious risks associated with both over-administering flumazenil and the removal of patient life-support and monitoring equipment before the benzodiazepines have worn off (due to flumazenil masking their continued effect).
Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zol-pidem,.
It may also be effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia.
It has also been used in hepatic encephalopathy, though results have been mixed.
The onset of action is rapid and usually effects are seen within one to two minutes. The peak effect is seen at six to ten minutes. The recommended dose for adults is 200 μg every 1-2 minutes until the effect is seen, to a maximum of 3 mg per hour. It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5 mL.

5. Flumazenil Specification

Items of analysisSpecificationResults
AppearanceWhite crystalline powderWhite Crystalline Powder  
IdentificationThe sample'S IR spectrum is according with spectrum of  Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparationConforms
Melting point198ºC to 202ºC200.6ºC to 200.9ºC
Appearance of solutionThe solution is clear and is not Intenser than reference solution BY7  Conforms
Impurity C NMT 0.2%0.02%
Impurity ANMT 0.10%Not detected
Impurity BNMT 0.2%0.03%
Impurity DNMT 0.10%0.03%
Impurity ENMT 0.10%Not detected
Impurity FNMT 0.10%Not detected
Individual unknown impurituyNMT 0.10%0.02%
Total impuritiesNMT 0.5%0.1%
Loss on dryingNMT 0.5%0.2%
Sulphated ashNMT 0.1%0.05%
Heavy metals≤0.5 ppm5ppm
Microbial limits( for Injection)Bacteria not more than 50CFU/g<10 CFU/g
Microbial limitsMildew and microzyme not more than 50CFU/g<10 CFU/g
Microbial limitsEscherichia coli absenceAbsence
EthanolNMT2000ppmNot detected
Chloroform  NMT30ppmNot detected
Acetic acid   NMT4000ppmNot detected
Ethyl ethanoateNMT5000ppm<0.003%
DMFNMT750ppmNot detected
Assay (On dried substance)98.0-102.0%99.80%
Bacterial endotoxinsnot more than 25.0 USP Endotoxin Units per mg of flumazenil.not more than 8.0 USP Endotoxin Units per mg of flumazenil.
Guarantees the nature time36 months36 months

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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]

Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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