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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Lapatinib Ditosylate CAS 388082-78-8 Antineoplastic Agents manufacturer

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Lapatinib Ditosylate CAS 388082-78-8 Antineoplastic Agents 

Qty (Other,ml) Unit Price (160.0~290.0 USD)
100 - 199 160
200 + 290
Payment Terms: T/T,WU,Money Gram;bitcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: HKYC
Production Capacity: 100000L/WEEK
Delivery Date: with 6 working hours
service: resend guarantee
Supply Ability: Mass Stock
Model Number: 231277-92-2 f
Usage: Pharmaceutical Raw
Shipping: 3-7 Days / Door-to-Door
Means of Transport: Air
Packing: brand new
package: Special disguised packaging...
Payment Terms: Western Union, MoneyGram, B...
Certification: ISO
Active-Life: 7-9 days
Lead Time: Within 12 Hours After Payme...

Pharmaceutical Raw Material Lapatinib CAS 231277-92-2 for Breast Cancer
Lapatinib Ditosylate CAS 388082-78-8 Antineoplastic Agents
Lapatinib




  • CAS No.: 388082-78-8

  • Other Names: Lapatinib ditosylate hydrate

  • MF: C41H40ClFN4O11S3

  • EINECS No.: 388082-78-8

  • Place of Origin: Shanghai, China (Mainland)

  • Type: Antineoplastic Agents

  • Grade Standard: Medicine Grade

  • Usage: Animal Pharmaceuticals

  • Brand Name:TwoChem

  • Purity: 99%

  • Appearance: White Powder

  • Application: API Used for the treatment of breast cancer.

The COA of this product :

ITEMSSPECIFICATIONTESTRESULTS
AppearanceOff-white or white powderConforms
IdentificationHPLC,NMR;LC-MSConforms
Related substancesIndividual impurity≤0.5%0.09%
Total impurities≤1.0%0.20%
Loss on drying≤0.5%0.3%
Residue on ignition≤0.1%0.04%
Heavy metals≤10ppmConforms
Assay≥98.0 %99.1%

Description:

Lapatinib (INN), used in the form of lapatinib ditosylate, (USAN) (Tykerb/Tyverb, GSK) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal receptor (EGFR) pathways.

It is used in combination therapy for HER2-positive breast cancer. It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2).
 


Usage:

1) Lapatinib is a breast cancer targeted therapy drug . Breast cancer molecular targeted therapy aims at the occurrence and development of cancer-related genes and their expression products of breast cancer for treatment. Molecular targeted drug by blocking signal transduction of tumor cells or associated cells , control changes in cell gene expression, in order to inhibit or kill tumor cells.

 

2) Lapatinib is a novel targeted anti-cancer drug. It Can act on Her-1 and Her-2 two targets at he same time, the biological effect of the inhibition of tumor cell proliferation and growth arising from this mode of action is much larger than acting on just one target. The so-called targeted therapy, refers to certain receptors, genes or proteins as a key target, and then targets to kill tumor cells related to drug.


Lapatinib ditosylate COA

TEST ITEMSSPECIFICATIONRESULTS
DescriptionLight yellow or almost white crystalline powderLight Yellow powder
IdentificationIRPositive
Assay97.0~103.0%99.37%
Melting Point70~80°C70.5~76.5°C
Specific Rotation+22~+26°+23.09°
Loss On Drying0.5%max0.25%
Residue On Ignition0.1%max0.05%
Heavy Metals20PPm max<20PPm
Organic Volatile ImpuritiesMeets the requirement.Conforms

Related Substances
Single Impurity: 1.0%max<1.0%
Total Impurities: 2.0%max<2.0%
ConclusionThe specification conforms to enterprise standard.


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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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