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Wuhan Yuancheng Gongchuang Technology Co,ltd
Wuhan Yuancheng Gongchuang Technology Co,ltd

China Sanvar Vapreotide Polypeptide For Treating Esophageal Variceal Bleeding manufacturer

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Gold Index: 167644

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Sanvar Vapreotide Polypeptide For Treating Esophageal Variceal Bleeding 

Qty (Other,ml) Unit Price (160.0~290.0 USD)
100 - 199 160
200 + 290
Payment Terms: T/T,WU,Money Gram;bitcoin 
Place of Origin: Hubei, China (Mainland) 
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Product Detail

Model No.: HKYC
Production Capacity: 100000L/WEEK
Delivery Date: with 6 working hours
service: resend guarantee
Supply Ability: Mass Stock
Model Number: 568-73-0
Usage: Pharmaceutical Raw
Shipping: 3-7 Days / Door-to-Door
Means of Transport: Air
Packing: brand new
package: Special disguised packaging...
Payment Terms: Western Union, MoneyGram, B...
Certification: ISO
Active-Life: 7-9 days
Lead Time: Within 12 Hours After Payme...

Sanvar Vapreotide Acetate Polypeptide For Treating Esophageal Variceal Bleeding
Sanvar Vapreotide Acetate Polypeptide For Treating Esophageal Varicea

Quick Details:
Vapreotide Acetate
Sequence: D-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2
Alias:Sanvar,RC-160;VAPREOTIDE;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2; Octastatin;
FCYWKVCW-NH2;D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Trp-NH2;
Cas No.: 103222-11-3
Molecular Formula: C57H70N12O9S2
Molecular Weight: 1131.40
Purity (HPLC): 98.0%
Appearance: White powder
Single Impurity(HPLC): 1.0%
Amino Acid Composition: 10% of theoretical
Peptide Content(N%): 80%(by %N)
Water Content(Karl Fischer): 6.0%
Acetate Content(HPIC): 15.0%
Mass Balance: 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8ºC preservation
Usage : The drug can be used for treatment of early acute esophageal variceal bleeding (EVB) and endoscopic interventional therapy before hemostasis, can also be bleeding within 5 d lens for the treatment and prevention of recurrence after endoscopic.vapreotide acetate will be the only approved treatment for esophageal variceal bleeding in the United States.
 

Description: 
1.Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis.

2.The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. In addition, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects.
 

Application:
1.The immediate release formulation of Sanvar, a somatostatin analogue, is used in the treatment of acute esophageal variceal bleeding (EVB).

2.Sanvar is used prior to endoscopic intervention to control haemorrhage and prevent re-bleeding during the critical five days following the onset of bleeding. EVB is a life threatening condition and the mortality rate is high (about 15% to 25%) in the first six weeks following the haemorrhage. EVB is the cause of about 70% of gastro-intestinal bleeding in patients suffering from liver cirrhosis.

3.Sanvar (vapreotide acetate) is a synthetic octapeptide analogue of the naturally-occurring somatostatin hormone. It has similar pharmacological properties to native somatostatin, but exhibits a longer duration of action. It is the only somatostatin analogue to have demonstrated statistically significant benefits in the early treatment of EVB in association with endoscopic therapy, in a placebo-controlled clinical study (Calès et al. New England Journal of Medicine, 2001). Control of bleeding with survival at five days was achieved more often with Sanvar (p=0.021) than with placebo. Additional

4.Phase III trials have been completed in Europe in this indication. Sanvar can be stored at room temperature, an advantage over other products requiring refrigeration, allowing immediate administration, a key benefit in a life-threatening situation. The product has been granted orphan drug status in the U.S., where there is currently no FDA approved treatment for this indication.


Competitive Advantage: 
1. Rich experience.
Our company is a professional steroid supplier in China over 15 years.Our products have been exported to Germany, Spain, UK, USA, Canada,Brazil,Australia, Middle East, and others.We got very good feedback from our customers, due to the quality of our steroid and professional experience in operating the business.
 
2. Great quality, purity and favourable.
Good quality is one of our secret of success,both raw powder and liquid steroids.
 
3.Safe and fast delivery.
There is also steroids at stock, so we can deliver them very quickly as soon as we got the payment,normally within 24 hours.
 
We have special way that could ship 0.01kg to 3.5kg products at one time. We also offer melting powder into liquid service.And can ship the liquid in special bottles.
 
4.Good after-sales service.
Tracking the package and updating it every day.Quick response and good communications,online 24 hours.

Ms. Gina
skype Ms. Gina
Manager
Tel: 86-27-88211875
Mobile: 188 7222 0799
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Company Info

Wuhan Yuancheng Gongchuang Technology Co,ltd [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Wuhan
Province/State: Hubei
Country/Region: China (Mainland)

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Gina:   skype
Service:   skype

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